Therapeutic index of inhaled corticosteroids in asthma: A dose-response comparison on airway hyperresponsiveness and adrenal axis suppression.

Peter T Daley-YatesNoushin BrealeySebin ThomasDaren AustinShaila ShabbirTim HarrisonDave SinghNeil Barnes

Published in: British journal of clinical pharmacology (2020)

This study provides evidence that FF can provide more protection against airway hyperresponsiveness, with less systemic activity, than FP or BUD. This suggests that all inhaled corticosteroids are not therapeutically similar and may differ in their therapeutic index. (203162; NCT02991859).

Keyphrases

cystic fibrosis
chronic obstructive pulmonary disease
lung function
allergic rhinitis
air pollution