p53 Acetylation Exerts Critical Roles in Pressure Overload-Induced Coronary Microvascular Dysfunction and Heart Failure in Mice.
Xiaochen HeAubrey C CantrellQuinesha A WilliamsWei GuYingjie ChenJian-Xiong ChenHeng ZengPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Our data reveal the importance of p53 acetylation in coronary microvascular function, cardiac function, and remodeling and may provide a promising approach to improve hypertension-induced CMD and to prevent the transition of cardiac hypertrophy to HF.
Keyphrases
- heart failure
- coronary artery disease
- high glucose
- diabetic rats
- coronary artery
- blood pressure
- oxidative stress
- atrial fibrillation
- gene expression
- electronic health record
- type diabetes
- dna methylation
- acute heart failure
- histone deacetylase
- adipose tissue
- skeletal muscle
- insulin resistance
- data analysis
- aortic valve
- transcatheter aortic valve replacement
- artificial intelligence
- wild type