IFNγ-producing NK cells in adipose tissue are associated with hyperglycemia and insulin resistance in obese women.
Denis A MogilenkoRobert CaiazzoLaurent L'hommeLaurent PineauVioleta RaverdyJerome NouletteBruno DerudasFrancois PattouBart StaelsDavid DombrowiczPublished in: International journal of obesity (2005) (2021)
Our results suggest that a distinct IFNγ-producing NK cell subset is involved in metabolic homeostasis in visceral AT in humans with obesity and may be a potential target for therapy of IR.
Keyphrases
- nk cells
- adipose tissue
- insulin resistance
- polycystic ovary syndrome
- metabolic syndrome
- weight loss
- high fat diet
- dendritic cells
- immune response
- high fat diet induced
- type diabetes
- skeletal muscle
- weight gain
- bariatric surgery
- pregnancy outcomes
- human health
- physical activity
- body mass index
- risk assessment
- bone marrow
- mesenchymal stem cells
- replacement therapy