Detecting a potential safety signal of antidepressants and type 2 diabetes: a pharmacovigilance-pharmacodynamic study.

Published in: British journal of clinical pharmacology (2018)

Most of the tricyclic antidepressants, mirtazapine and sertraline seem to be associated with reporting diabetes in FAERS. Higher degrees of occupancy on muscarinic receptors and H1 may be a plausible pharmacological mechanism. Further clinical assessment and pharmacovigilance data is needed to validate this potential safety signal.

Keyphrases

type diabetes
adverse drug
major depressive disorder
glycemic control
cardiovascular disease
electronic health record
drug induced
human health
emergency department
big data
risk assessment
machine learning
metabolic syndrome
skeletal muscle