Interaction between tumor cell TNFR2 and monocyte membrane-bound TNF-α triggers tumorigenic inflammation in neuroblastoma.
Julie A TomolonisXin XuKshiti H DholakiaChunchao ZhangLinjie GuoAmy N CourtneySiyue WangJulien BalzeauGabriel A BarragánGengwen TianErica J Di PierroLeonid S MetelitsaPublished in: Journal for immunotherapy of cancer (2023)
We have described a novel mechanism of tumor-promoting inflammation in NB that is strongly associated with patient outcome and could be targeted with therapy.