Group 2 innate lymphoid cells are numerically and functionally deficient in the triple transgenic mouse model of Alzheimer's disease.

Ivan Ting Hin FungYuanyue ZhangDamian S ShinPoornima SankarXiangwan SunShanti S D'SouzaRenjie SongMarcy L KuentzelSridar V ChitturKristen L ZuloagaQi Yang

Published in: Journal of neuroinflammation (2021)

Our results collectively indicate that numerical and functional deficiency of ILC2 might contribute to the cognitive impairment of 3xTg-AD mice.

Keyphrases

cognitive impairment
mouse model
induced apoptosis
cell cycle arrest
cognitive decline
wild type
high fat diet induced
endoplasmic reticulum stress
signaling pathway
oxidative stress
type diabetes
cell death
metabolic syndrome
cell proliferation
nk cells
smoking cessation