Aspirin in the Form of Microneedle Repairs DNA and Reduces Inflammation in Persistent Skin Damage.
Wenbin CaoHuanchun XingShuai GuoLin WangXin SuiLijuan HuangYuan LuoJun YangYongan WangPublished in: Biomaterials research (2024)
Skin damage caused by chemical corrosion is currently one of the common skin diseases and poisoning symptoms, with nitrogen mustard compounds causing the most persistent and severe damage. These chemicals penetrate the top layer of the skin, enter the dermis, and cause DNA damage, oxidative stress, and inflammation. However, to date, no effective drug treatment has been found. Even the potential antidotes could not effectively penetrate the top layer of the skin to exert their effects due to the skin barrier. To address this problem, an innovative transdermal drug delivery strategy based on aspirin microneedles was proposed. The classic medicine aspirin was first discovered not only to reduce inflammation and oxidative stress but also to promote DNA repair and reduce DNA damage. The aspirin microneedles directly delivered the drug to the damaged area, released aspirin through the skin barrier, and exhibited good biocompatibility. These findings indicate that aspirin microneedles have great potential for promoting wound healing and broad application prospects.
Keyphrases
- oxidative stress
- dna damage
- wound healing
- low dose
- dna repair
- soft tissue
- cardiovascular events
- antiplatelet therapy
- diabetic rats
- drug delivery
- ischemia reperfusion injury
- induced apoptosis
- cardiovascular disease
- emergency department
- type diabetes
- anti inflammatory drugs
- depressive symptoms
- percutaneous coronary intervention
- single molecule
- drug induced
- circulating tumor cells
- human health
- sleep quality