Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma.
Runzhe ChenJun LiJunya FujimotoLingzhi HongXin HuKelly QuekMing TangAkash MitraCarmen BehrensChi-Wan ChowPeixin JiangLatasha D LittleCurtis GumbsXingzhi SongJianhua ZhangDongfeng TanJohn V HeymachIgnacio WistubaP Andrew FutrealDon L GibbonsLauren A ByersJianjun ZhangAlexandre ReubenPublished in: Journal of experimental & clinical cancer research : CR (2022)
Our study demonstrates heterogeneous genomic and T cell profiles across synchronous metastases and how restriction of unique T cell clonotypes within an individual may differentially shape the genomic and epigenomic landscapes of synchronous lung metastases.