Anti-inflammatory effects of Sanguisorbae Radix water extract on the suppression of mast cell degranulation and STAT-1/Jak-2 activation in BMMCs and HaCaT keratinocytes.

Ju-Hye YangJae-Myung YooWon-Kyung ChoJin Yeul Ma

Published in: BMC complementary and alternative medicine (2016)

This results demonstrate that WSR inhibits degranulation of IgE/Ag-activated mast cells and inhibits the production of pro-inflammatory chemokines by suppressing the phosphorylation of p38 and JNK in HaCaT cells.

Keyphrases

induced apoptosis
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
signaling pathway
cell death
cell proliferation
quantum dots
protein kinase
highly efficient