The SARS-CoV-2 spike N-terminal domain engages 9- O -acetylated α2-8-linked sialic acids.

Ilhan TomrisLuca UnioneLinh NguyenPouya ZareeKim M BouwmanLin LiuZeshi LiJelle A FokMaría Ríos CarrascoRoosmarijn van der WoudeAnne L M KimpelMirte W LinthorstEnrico C J M VerpalenTom G CanielsRogier W SandersBalthasar A HeestersRoland J PietersJesús Jiménez-BarberoJohn S KlassenGeert-Jan BoonsRobert P de Vries

Published in: bioRxiv : the preprint server for biology (2022)

-acetylated sialic acid using its NTD. This binding functionality was selected against rapidly, most likely due to poor dissemination. Ablation of sialic acid binding in more recent SARS-CoV-2 Variants of Concern suggests a fine balance of sialic acid interaction of SARS-CoV-2 is required for infection and/or transmission.

Keyphrases

sars cov
respiratory syndrome coronavirus
air pollution
copy number
transcription factor