NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias.
Larry ScottAnke C FenderArnela SaljicLuge LiXiaohui ChenXiaolei WangDominik K LinzJilu LangMathias HohlDarragh TwomeyThuy T PhamRodrigo Diaz LankenauMihail G CheluMarkus KamlerMark L EntmanGeorge E TaffetPrashanthan SandersDobromir DobrevNa LiPublished in: Cardiovascular research (2022)
These results demonstrate that the atrial NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmogenesis and establishes a mechanistic link between obesity-induced AF and NLRP3-inflammasome activation.