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The dynamic nature of senescence in cancer.

Soyoung LeeClemens A Schmitt
Published in: Nature cell biology (2019)
Cellular senescence is implicated in physiological and pathological processes spanning development, wound healing, age-related decline in organ functions and cancer. Here, we discuss cell-autonomous and non-cell-autonomous properties of senescence in the context of tumour formation and anticancer therapy, and characterize these properties, such as reprogramming into stemness, tissue remodelling and immune crosstalk, as far more dynamic than suggested by the common view of senescence as an irreversible, static condition.
Keyphrases
  • dna damage
  • endothelial cells
  • papillary thyroid
  • stress induced
  • cell therapy
  • single cell
  • squamous cell
  • stem cells
  • wound healing
  • lymph node metastasis
  • oxidative stress
  • mesenchymal stem cells
  • bone marrow