EphA3 targeting reduces in vitro adhesion and invasion and in vivo growth and angiogenesis of multiple myeloma cells.
Francesco La RoccaIrma AiroldiEmma Di CarloPina MarottaGeppino FalcoVittorio SimeonIlaria LaurenzanaStefania TrinoLuciana De LucaKatia TodoertiOreste VillaniMartin LackmannFiorella D'AuriaFrancesco FrassoniAntonino NeriLuigi Del VecchioPellegrino MustoDaniela CilloniAntonella CaivanoPublished in: Cellular oncology (Dordrecht) (2017)
Our findings suggest that EphA3 plays an important role in the pathogenesis of MM and provide support for the notion that its targeting may represent a novel therapeutic opportunity for MM.