Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry.
Edgar Carnero ContenttiPablo Adrian LopezJuan Pablo PettinicchiJuan CrinitiAgustín PappollaJimena MiguezEdgardo CristianoLiliana PatruccoSusana LiwackiVerónica TkachukMaría E BalbuenaCarlos VrechNorma DeriJorge CorrealeMariano MarrodanMaría C YsrraelitFelisa LeguizamonGeraldine LueticMaría L MenichiniDarío TavoliniCarolina MainellaGisela ZangaMarcos BurgosJavier HrybAndrés BarbozaLuciana LazaroRicardo AlonsoNora Fernández LiguoriDébora NadurMarina Alonso SerenaAlejandro CarideFriedemann PaulJuan I RojasPublished in: Multiple sclerosis journal - experimental, translational and clinical (2023)
We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) patients died after 11 years of follow-up for a total exposure time of 53,345 days with an overall incidence density of 2.06 × 10.000 patients/day (95% CI 1.75-2.68). Extensive cervical myelitis with respiratory failure (45%) was the most frequent cause of death. Older age (HR = 2.05, p = 0.002) and higher disability score (HR = 2.30, p < 0.001) at disease onset were independent predictors of death. We found an 11-year mortality rate of 7% in Argentinean NMOSD patients.