High-Throughput Sequencing of Gastric Cancer Patients: Unravelling Genetic Predispositions Towards an Early-Onset Subtype.

Julita Machlowska Przemysław Kapusta Jacek BajFolkert H M MorsinkPawel P WolkowRyszard MaciejewskiG Johan A OfferhausRobert Sitarz

Published in: Cancers (2020)

The technology of next-generation sequencing is a useful tool for studying the development and progression of gastric carcinoma in a high-throughput way. Our study revealed that early-onset gastric cancer has a different mutation frequency profile in certain genes compared to conventional subtype.

Keyphrases

early onset
late onset
high throughput
end stage renal disease
high throughput sequencing
genome wide
ejection fraction
chronic kidney disease
newly diagnosed
copy number
prognostic factors
gene expression
transcription factor
dna methylation