Clinical and genetic characterization of familial central precocious puberty.

Flávia Rezende TinanoAna Pinheiro Machado CantonLuciana R MontenegroAndrea de Castro LealAline G FariaCarlos Eduardo SeraphimRaja BraunerAlexander A JorgeBerenice B MendoncaJesús ArgenteVinicius N BritoAna Claudia L Xavier

Published in: The Journal of clinical endocrinology and metabolism (2023)

We demonstrated a similar prevalence of familial CPP with maternal and paternal transmission. MKRN3 and DLK1 loss-of-function mutations were the major causes of familial CPP with paternal transmission.

Keyphrases

early onset
risk factors
pregnant women
physical activity
pregnancy outcomes
body mass index