RNF20 is required for male fertility through regulation of H2B ubiquitination in the Sertoli cells.

Fengling LaiHaoyu WangXinyue ZhaoKangning YangLe CaiMengxin HuLan LinXizhong XiaWei LiHanhua ChengRongjia Zhou

Published in: Cell & bioscience (2023)

This study describes a Rnf20 knockout mouse model that recapitulates the Sertoli cell-only syndrome in humans and demonstrates that RNF20 is required for male fertility through regulation of H2B ubiquitination in the Sertoli cells.

Keyphrases

induced apoptosis
mouse model
cell cycle arrest
single cell
oxidative stress
signaling pathway
cell therapy
bone marrow
mesenchymal stem cells
young adults