The deubiquitinase USP44 enhances cisplatin chemosensitivity through stabilizing STUB1 to promote LRPPRC degradation in neuroblastoma.
Liang ZengYing-Qing LiShi-Wei HeHui XuRuizhong ZhangKai ChenLiang-Jun QinXun-Hua ZhuYi-Lin LiLe LiNa LiuHai-Yun WangPublished in: Neuro-oncology (2024)
Our findings demonstrate that the USP44-STUB1-LRPPRC axis plays a pivotal role in neuroblastoma chemoresistance and provides potential targets for neuroblastoma therapy and prognostication.
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