The PYY/Y2R-Deficient Mouse Responds Normally to High-Fat Diet and Gastric Bypass Surgery.
Brandon BolandMichael B MumphreyZheng HaoBenji GillR Leigh TownsendSangho YuHeike MünzbergChristopher D MorrisonJames L TrevaskisHans-Rudolf BerthoudPublished in: Nutrients (2019)
PYY signaling through Y2R is not required for the normal appetite-suppressing and body weight-lowering effects of RYGB in this global knockout mouse model. Potential compensatory adaptations of PYY signaling through other receptor subtypes or other gut satiety hormones such as glucagon-like peptide-1 (GLP-1) remain to be investigated.
Keyphrases
- body weight
- high fat diet
- gastric bypass
- roux en y gastric bypass
- weight loss
- mouse model
- insulin resistance
- adipose tissue
- obese patients
- minimally invasive
- bariatric surgery
- signaling pathway
- coronary artery bypass
- type diabetes
- atomic force microscopy
- surgical site infection
- skeletal muscle
- wild type
- coronary artery disease
- risk assessment
- atrial fibrillation