Characterization of hepatitis delta virus strains spreading in Abuja, Nigeria.
Ijeoma Maryjoy IfeorahTemitope Oluwasegun Cephas FaleyeAdeleye Solomon BakareyMoses Olubusuyi AdewumiAthenais GerberFrédéric Le GalJohnson A AdenijiEmmanuel GordienNgozi F OnyemelukwePublished in: Journal of medical virology (2019)
Hepatitis delta virus (HDV) is responsible for the most severe form of liver disease in humans. So far, eight genotypes (HDV-1 to -8) have been individualized worldwide. Little is known about HDV strains that spread in Nigeria. HDV genotyping was performed in 15 anti-HDV positive samples from a cohort of 306 hepatitis B virus (HBV)-infected patients in Abuja (Nigeria). Phylogenetic analyses revealed 90% were HDV-1, two among them clustering with European/Asian HDV-1, the remaining one being HDV-6. It was also found that two members of a couple superinfected with the same HDV strain, were enveloped by two different HBV strains of genotype E.