Evaluation of DNA methylation biomarkers ASCL1 and LHX8 on HPV-positive self-collected samples from primary HPV-based screening.

Lisanne VerhoefMaaike C G BleekerNicole PolmanRenske D M SteenbergenRenée M F EbischWillem J G MelchersRuud L M BekkersAnco C MolijnWim G QuintFolkert van KemenadeChris J L M MeijerJohannes BerkhofDaniëlle A M Heideman

Published in: British journal of cancer (2023)

The ASCL1/LHX8 methylation marker panel constitutes a feasible direct triage method for the detection of CIN3 + in HPV-positive women participating in routine screening by self-sampling.

Keyphrases

cervical cancer screening
dna methylation
high grade
genome wide
emergency department
polycystic ovary syndrome
gene expression
metabolic syndrome
type diabetes
clinical practice
copy number
insulin resistance
pregnancy outcomes
quantum dots
skeletal muscle