Circulating T Cell Subsets and ILC2s are Altered in Patients With Chronic Rhinosinusitis With Nasal Polyps After Dupilumab Treatment.

Toshiyuki MatsuyamaHideyuki TakahashiHiroe TadaKazuaki Chikamatsu

Published in: American journal of rhinology & allergy (2022)

Our findings suggest that in CRSwNP patients treated with dupilumab, Th2, Treg, and ILC2 cells, which regulate type 2 inflammation, are modulated in the peripheral circulation. Further analysis of circulating immune cells could provide novel insights into understanding the pathophysiologic mechanisms of dupilumab and the development of tailored therapeutic strategies for patients with CRSwNP.

Keyphrases

chronic rhinosinusitis
atopic dermatitis
induced apoptosis
oxidative stress
cell cycle arrest
nk cells
peripheral blood
endoplasmic reticulum stress
combination therapy
chemotherapy induced
pi k akt