p62-mediated autophagy affects nutrition-dependent insulin receptor substrate 1 dynamics in 3T3-L1 preadipocytes.
Hirobumi IgawaAkihiro KikuchiHirofumi MisuKiyo-Aki IshiiShuichi KanekoToshinari TakamuraPublished in: Journal of diabetes investigation (2018)
Autophagy through p62 plays an important role in regulating IRS-1 protein levels in response to nutritional deficiency. The present findings suggest that autophagy might function as energy depletion-sensing machinery that finely tunes insulin signal transduction.