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p62-mediated autophagy affects nutrition-dependent insulin receptor substrate 1 dynamics in 3T3-L1 preadipocytes.

Hirobumi IgawaAkihiro KikuchiHirofumi MisuKiyo-Aki IshiiShuichi KanekoToshinari Takamura
Published in: Journal of diabetes investigation (2018)
Autophagy through p62 plays an important role in regulating IRS-1 protein levels in response to nutritional deficiency. The present findings suggest that autophagy might function as energy depletion-sensing machinery that finely tunes insulin signal transduction.
Keyphrases
  • cell death
  • endoplasmic reticulum stress
  • type diabetes
  • signaling pathway
  • oxidative stress
  • glycemic control
  • physical activity
  • skeletal muscle
  • replacement therapy
  • smoking cessation