Comprehensive analysis of cutaneous and uveal melanoma liver metastases.
Esmée P HoefsmitElisa A RozemanTrieu My VanPetros DimitriadisOscar KrijgsmanJordan W ConwayInes Pires da SilvaJacqueline E van der WalSteven L C KetelaarsKaspar BresserAnnegien BroeksRon M KerkhovenJason W ReevesSarah WarrenPia KvistborgRichard A ScolyerEllen W KapiteijnDaniel S PeeperGeorgina V LongTon N M SchumacherChristian U BlankPublished in: Journal for immunotherapy of cancer (2021)
While TMB was different between CM and UM metastases, tumor immune infiltration was similar. The greater dependency on PD-L1 as an immune checkpoint in CM and the identification of higher exhaustion ratios in UM may both serve as explanations for the difference in response to ICB. Consequently, in order to improve current treatment for metastatic UM, reversal of T cell exhaustion beyond programmed cell death 1 blockade should be considered.