Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase-1.

Sodiq O WaheedAnn VargheseIsabella DiCastriBrenden KaskiCiara LaRoucheGregg B FieldsTatyana G Karabencheva-Christova

Published in: Chemphyschem : a European journal of chemical physics and physical chemistry (2023)

The front cover artwork is provided by Dr. Karabencheva-Christova's group at Michigan Technological University. The images show the initially formed and the catalytically productive conformations of MMP-1 complex with the Triple Helical Peptide (THP), the free energy profile connecting them as well as the coordination geometry of the catalytic zinc (II). The background shows the collagen macromolecule. Read the full text of the Research Article at 10.1002/cphc.202200649.

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