Effects of a Macroporous Resin Extract of Dendrobium officinale Leaves in Rats with Hyperuricemia Induced by Anthropomorphic Unhealthy Lifestyle.

Lin-Zi Li Xi-Ming Wang Xiao-Jie Feng Kun Liu Bo Li Li-Jie Zhu Wan-Feng Xu Xiang Zheng Ying-Jie Dong Xing-Lishang He Hao-Ru Guan Yan-Yan Ding Han-Song Wu Chuan-Jie Zhou Sen-Yu Ye Bei-Bei Zhang Gui-Yuan Lv Su-Hong Chen

Published in: Evidence-based complementary and alternative medicine : eCAM (2023)

DoMRE demonstrated anti-HUA effects in the HUA rat model induced by an anthropomorphic unhealthy lifestyle, and the molecular mechanism appeared to involve the regulation of urate transport-related transporters (ABCG2 and GLUT9) in the intestine, protection of the intestinal barrier function to promote UA excretion, and inhibition of XOD and ADA activity in the liver and intestine to inhibit UA production in the HUA-induced rats.

Keyphrases

metabolic syndrome
physical activity
weight loss
cardiovascular disease
oxidative stress
high glucose
uric acid
diabetic rats
drug induced
type diabetes
endothelial cells
stress induced