Replacing device-measured sedentary time with physical activity is associated with lower risk of coronary heart disease regardless of genetic risk.
Youngwon KimHaeyoon JangMengyao WangQiaoxin ShiTessa StrainStephen J SharpShiu Lun Ryan Au YeungShan LuoSimon GriffinNicholas J WarehamKatrien WijndaeleSoren BragePublished in: Journal of internal medicine (2023)
Replacing any amount of ST with an equal amount of MVPA time is associated with a lower relative risk of CHD, irrespective of genetic susceptibility to CHD. Reductions in CHD absolute risk for replacing ST with MVPA are greater at high genetic risk versus low genetic risk.