Dual-Effective Chronic Wounds Management System through a Monoglyceride Binary Blend Matrix Based Thermal-Responsive Phase-Transition Substrate.
Liguo JinHaoxin ChengXuanping XieXinyu ChenGuangqi TianZhenling ZhuShuhua WangHongbo XinXiaolei WangPublished in: Advanced healthcare materials (2021)
A new monoglyceride-based heat-sensitive substrate is proposed, for the first time, as a wound management system. First, an appropriate portion of glyceryl monooleate (GMO) and glyceryl monostearate (GMS) is mixed to provide a thermal phase responsive matrix (GMO-GMS, GG). Subsequently, to improve the photothermal responsive and antibacterial performance, silver nanoparticles (Ag) decorated reduced graphene oxide (rGO) nanocomposite (rGO-Ag) is added to the GG matrix to obtain (GG-rGO-Ag). According to the systematic studies from uninfected, infected, and diabetic wound models, by applying near infrared (NIR) laser, the phase change of GG-rGO-Ag can be triggered to release Ag on demand for sterilization. More importantly, this smart GG substrate can also promote the production of vascular endothelial growth factor protein, thus serving as a NIR defined mufti-effective wound management system.
Keyphrases
- reduced graphene oxide
- gold nanoparticles
- quantum dots
- visible light
- silver nanoparticles
- vascular endothelial growth factor
- cancer therapy
- wound healing
- highly efficient
- photodynamic therapy
- amino acid
- type diabetes
- drug delivery
- hiv infected
- fluorescent probe
- fluorescence imaging
- small molecule
- high resolution
- structural basis
- case control
- anti inflammatory