Biclustering reveals potential knee OA phenotypes in exploratory analyses: Data from the Osteoarthritis Initiative.
Amanda E NelsonThomas H KeefeTodd A SchwartzLeigh F CallahanRichard F LoeserYvonne M GolightlyLiubov ArbeevaJ S MarronPublished in: PloS one (2022)
We identified six biclusters within the baseline OAI dataset which have varying relationships with key outcomes in KOA. Such biclusters represent potential phenotypes within the larger cohort and may suggest subgroups at greater or lesser risk of progression over time.