Comparison of Gene Transfection and Cytotoxicity Mechanisms of Linear Poly(amidoamine) and Branched Poly(ethyleneimine) Polyplexes.

Ammar A Y AlmulathanonElisabetta RanucciPaolo FerrutiMartin C GarnettCynthia Bosquillon

Published in: Pharmaceutical research (2018)

PAA polyplexes displayed a pH-dependent endo/lysosomal escape which was not associated with cytotoxic events, unlike observed with BPEI polyplexes. This is likely due to their greater interactions with biological membranes at acidic than neutral pH.

Keyphrases

copy number
genome wide
ionic liquid
gene expression
genome wide identification
anti inflammatory