Progenitor with cardiometabolic disorders increases food intake, systemic inflammation and gut microbiota alterations in the second-generation offspring.

This work presents the effects of the high-fat diet (H) consumed by the progenitor (G 0 ) on cardiometabolic disorders and intestinal microbiota in the second-generation offspring (F 2 ). The rats submitted to H (G 0 H) or control (C) (G 0 C) diets, during mating, gestation and lactation, generated F 2 offspring (F 2 -G 0 H and F 2 -G 0 C, respectively), which received only the C diet. Both, G 0 H and F 2 -G 0 H, showed changes in the intestinal microbiota, increased MAP, plasma TAG levels, adiposity index and the inflammatory process in retroperitoneal fat and in the colon shown by increased TNF-α, MCP-1, MyD88 and CAV-1 gene expression. In addition, F 2 -G 0 H showed increased food intake, leptin resistance, total cholesterol and plasma levels of MCP-1 and reduced adiponectin. Regarding microbial communities, a greater diversity was observed in 5 unique families of bacteria that was correlated with cardiometabolic disorders. Overall, progenitors with cardiometabolic disorders induce an increase in food intake, systemic inflammation and microbiota alterations in the F 2 -G 0 H offspring.