Novel Molecular and Phenotypic Insights into Congenital Lung Malformations.

Daniel T SwarrWilliam H PeranteauJennifer PogorilerDavid B FrankN Scott AdzickHolly L HedrickMike MorleySu ZhouEdward E Morrisey

Published in: American journal of respiratory and critical care medicine (2019)

This study provides the first comprehensive analysis of the congenital lung malformation transcriptome and suggests that disruptions in Ras or PI3K-AKT-mTOR signaling may contribute to the pathology through an epithelial cell-autonomous defect.

Keyphrases

gene expression
rna seq
genome wide
single molecule
wild type