Role of metabolites of cyclophosphamide in cardiotoxicity.

Koichiro KurauchiTakuro NishikawaEmiko MiyaharaYasuhiro OkamotoYoshifumi Kawano

Published in: BMC research notes (2017)

Increased ROS generation and decreased ALDH activity confirmed that CY metabolites HCY and acrolein are strongly implicated in cardiotoxicity. By inhibiting ROS generation, increasing ALDH activity and decreasing the presence of acrolein, NAC has the potential to prevent CY-induced cardiotoxicity.

Keyphrases

ms ms
cell death
dna damage
reactive oxygen species
transcription factor
signaling pathway
high glucose
high dose
diabetic rats
risk assessment