DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.
Lingfang ZhuangKangni JiaChen ChenZhigang LiJiaxin ZhaoJian HuHang ZhangQin FanChunkai HuangHongyang XieLin LuWeifeng ShenGuang NingJiqiu WangRuiyan ZhangKang ChenXiaoxiang YanPublished in: Circulation (2022)
Taken together, the findings of this study provide new insights into the previously unrecognized role of DYRK1B in mitochondrial bioenergetics and the progression of cardiac hypertrophy and heart failure. Consequently, these findings may provide new therapeutic options for patients with heart failure.