Opioid-induced microbial dysbiosis disrupts irinotecan (CPT-11) metabolism and increases gastrointestinal toxicity in a murine model.

Jingjing MengYaa F AbuYue ZhangYuyin ZhouYun XieYan YanJunyi TaoSundaram RamakrishnanChi ChenSabita Roy

Published in: British journal of pharmacology (2022)

Gut microbiota play a significant role in opioid and chemotherapeutic agent drug-drug interactions. Inhibition of gut microbial glucuronidase may also prevent adverse GI effects of CPT-11 in patients on opioids.

Keyphrases

chronic pain
pain management
end stage renal disease
microbial community
chronic kidney disease
newly diagnosed
oxidative stress
prognostic factors
peritoneal dialysis
drug induced
diabetic rats
high glucose
emergency department
endothelial cells
patient reported
stress induced