Viral kinetics analysis and virological characterization of treatment failures in patients with chronic hepatitis C treated with sofosbuvir and an NS5A inhibitor.
Slim FouratiJ GuedjS ChevaliezT H T NguyenF Roudot-ThoravalI RuizA SoulierG ScoazecA VarautL PoiteauM FrancoisA MallatC HézodeJ-M PawlotskyPublished in: Alimentary pharmacology & therapeutics (2017)
This real-world study confirms the excellent results of clinical trials with therapies based on a combination of SOF plus an NS5A inhibitor. It suggests that a personalized approach including baseline NS5A inhibitor resistance testing may inform treatment decisions in cirrhotic patients.