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Viral kinetics analysis and virological characterization of treatment failures in patients with chronic hepatitis C treated with sofosbuvir and an NS5A inhibitor.

Slim FouratiJ GuedjS ChevaliezT H T NguyenF Roudot-ThoravalI RuizA SoulierG ScoazecA VarautL PoiteauM FrancoisA MallatC HézodeJ-M Pawlotsky
Published in: Alimentary pharmacology & therapeutics (2017)
This real-world study confirms the excellent results of clinical trials with therapies based on a combination of SOF plus an NS5A inhibitor. It suggests that a personalized approach including baseline NS5A inhibitor resistance testing may inform treatment decisions in cirrhotic patients.
Keyphrases
  • clinical trial
  • end stage renal disease
  • chronic kidney disease
  • ejection fraction
  • hepatitis c virus
  • sars cov
  • hiv infected
  • peritoneal dialysis
  • combination therapy
  • zika virus
  • double blind
  • aqueous solution