Biological sex and BMI influence the longitudinal evolution of adolescent and young adult MRI-visible perivascular spaces.

Erin A YamamotoSeiji KoikeCaitlyn WongLaura E DennisMadison N LutherAvery ScatenaSeva KhambadkoneJeffrey J Iliff Miranda M LimSwati R LevendovszkyJonathan E ElliottGiuseppe BarisanoEva M Müller-OehringAngelica M MoralesFiona C Baker Bonnie J Nagel Juan A Piantino

Published in: bioRxiv : the preprint server for biology (2024)

This longitudinal study showed sex differences in MV-PVS features during adolescence and young adulthood. Importantly, we report that increases in BMI from a person's mean BMI are associated with increases in MV-PVS volume in females only. These findings suggest a potential link between MV-PVS, sex, and BMI that warrants future study.

Keyphrases

body mass index
young adults
weight gain
depressive symptoms
magnetic resonance imaging
mental health
computed tomography
contrast enhanced
early life
climate change
diffusion weighted imaging
human health