Rituximab in combination with adapted-dose of ifosfamide and etoposide as salvage treatment in elderly refractory/relapsed diffuse large B-cell lymphoma patients non-candidate for high dose therapy: a retrospective study.
Guillaume AussedatDelphine Maucort-BoulchPhilippe ReyViolaine SafarLionel KarlinMad Helenie ElsensohnEmmanuel BachyLaure LebrasBertrand FavierNicolas VantardDana GhergusCamille GolfierPierre SesquesAnne LazarethHélène LequeuEmmanuelle FerrantGilles SallesEmmanuelle Nicolas-VirelizierHervé GhesquièresPublished in: Leukemia & lymphoma (2021)
We retrospectively reviewed for 72 relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) patients ineligible for autologous stem-cell transplantation (ASCT) treated between 2004 and 2017, efficacy and safety profile of rituximab (375 mg/m2) in combination with etoposide (300 mg/m2) and ifosfamide (1500 mg/m2) at 2, 3, or 4-week intervals. Median age was 79 years (range, 64-92). The median number of previous line was 1 (range 1-8). Patients received a median of six cycles (1-12). Fourteen patients (19%) presented partial and 14 complete responses (19%). Among the 369 cycles, nine patients developed febrile neutropenia (13%), 14 a grade 3-4 neutropenia (19%), 7 a grade 3-4 thrombocytopenia (10%) without grade 3-4 non-hematological toxicity. With a median follow up of 7.8 months, the median progression-free survival, overall survival, and duration of response were 4.4 months, 9.4 months, and 12 months, respectively. This regimen represents a therapeutic option in R/R DLBCL patients ineligible to ASCT.
Keyphrases
- diffuse large b cell lymphoma
- end stage renal disease
- ejection fraction
- newly diagnosed
- high dose
- chronic kidney disease
- stem cell transplantation
- peritoneal dialysis
- acute lymphoblastic leukemia
- prognostic factors
- clinical trial
- acute myeloid leukemia
- bone marrow
- epstein barr virus
- mesenchymal stem cells
- study protocol
- patient reported
- urinary tract infection
- chronic lymphocytic leukemia
- smoking cessation