Polygenic risk score and biochemical/environmental variables predict a low-risk profile of age-related macular degeneration in Sardinia.

Rita SerraVincenzo RalloAntonio PinnaMaristella SteriMaria Grazia PirasMichele MarongiuFlorence CoscasMyriam GorospeDavid SchlessingerEdoardo FiorilloFrancesco CuccaAndrea Angius

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2022)

In our cohort, most subjects showed no sign of any AMD type and late AMD was a condition rarely observed. Results of genetic, biochemical, and life-style investigation support the hypothesis that Sardinia population may present of a peculiar background with a protective effect against AMD development.

Keyphrases

age related macular degeneration
genome wide
copy number
human health
gene expression
risk assessment
climate change