Non-targeted metabolomics identify polyamine metabolite acisoga as novel biomarker for reduced left ventricular function.

Andreas PuetzAnna ArtatiJerzy AdamskiKatharina SchuettFrancesco RomeoRobert StoehrNikolaus MarxMassimo FedericiMichael LehrkeBen A Kappel

Published in: ESC heart failure (2021)

We found the polyamine metabolite acisoga to be elevated in patients with impaired LV-EF in two independent cohorts. Our analyses suggest that acisoga may be a valuable biomarker to detect patients with heart failure with reduced ejection fraction.

Keyphrases

left ventricular
mass spectrometry
heart failure
cancer therapy
acute myocardial infarction
hypertrophic cardiomyopathy
mitral valve
cardiac resynchronization therapy
drug delivery
aortic valve
percutaneous coronary intervention