Impact of penalizing factor in a block-sequential regularized expectation maximization reconstruction algorithm for 18F-fluorocholine PET-CT regarding image quality and interpretation.

To achieve acceptable image quality at 4 MBq/kg 18F-FCH, we propose using a β of 400-550 with a frame duration of 1.5 min. The lower β should be used if a high CNR is desired and the higher if a low noise level is important.