Cyp4a12-mediated retinol metabolism in stellate cells is the antihepatic fibrosis mechanism of the Chinese medicine Fuzheng Huayu recipe.

Da-Bing PingXin SunYuan PengCheng-Hai Liu

Published in: Chinese medicine (2023)

Our findings revealed a new role for Cyp4a in retinol metabolism in the development of hepatic fibrosis, and they highlight Cyp4a12/Rae-1 signals as possible therapeutic targets for antifibrotic medicines.

Keyphrases

induced apoptosis
cell cycle arrest
single cell
liver fibrosis
oxidative stress
endoplasmic reticulum stress
signaling pathway
cell death
pi k akt