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Suvorexant enhances oxycodone-induced respiratory depression in male rats.

Eliseu D C Moreira-JuniorJames K RowlettLais F Berro
Published in: Drug and alcohol dependence (2024)
Our findings show that suvorexant, at a dose associated with sleep promotion and blockade of oxycodone self-administration, robustly enhanced oxycodone-induced respiratory depression in male rats.
Keyphrases
  • high glucose
  • sleep quality
  • diabetic rats
  • depressive symptoms
  • physical activity
  • oxidative stress
  • endothelial cells