Longitudinal SARS-CoV-2 neutralization of Omicron BA.1, BA.5 and BQ.1.1 after four vaccinations and the impact of breakthrough infections in haemodialysis patients.

Louise PlatenBo-Hung LiaoMyriam TellenbachCho-Chin ChengChristopher Holzmann-LittigCatharina ChristaChristopher DächertVerena KapplerRomina BesterMaia Lucia WerzEmely SchönhalsEva PlatenPeter EggererLaëtitia TréguerClaudius KüchleChristoph SchmadererUwe HeemannOliver T KepplerLutz RendersMatthias Christoph BraunischUlrike Protzer

Published in: Clinical kidney journal (2023)

SARS-CoV-2-naïve HD patients had significantly decreased virus neutralization capacity 6 months after the fourth vaccination, whereas patients with a SARS-CoV-2 infection had no change in neutralization capacity. This was independent of age, sex, dialysis vintage and immunosuppression. Therefore, in infection-naïve HD patients a fifth COVID-19 vaccination might be reasonable 6 months after the fourth vaccination.

Keyphrases

end stage renal disease
sars cov
chronic kidney disease
ejection fraction
peritoneal dialysis
newly diagnosed
prognostic factors
coronavirus disease