Nonlinear Relationship Between C-Reactive Protein and Depression Among Obese Middle-Aged Adults.

Assuming linearity for the CRP association with depression may not be appropriate for middle-aged obese women. While we do not claim to provide a definite method of assessing the CRP-depression relationship, we hope to offer a different perspective when exploring this relationship. Thus, the results should be interpreted cautiously, and future studies on this topic should replicate this approach with GAMs.