IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia.
Fátima Rivera-EscaleraJonathan J PinneyLaura OwlettHoda AhmedJuilee ThakarJohn A OlschowkaMichael R ElliottM Kerry O'BanionPublished in: Journal of neuroinflammation (2019)
These studies show that IL-1β overexpression early in amyloid pathogenesis induces a change in the microglial gene expression profile and an expansion of microglial cells that facilitates Aβ plaque clearance.
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