Discovery of GuaB inhibitors with efficacy against Acinetobacter baumannii infection.
Eric M KofoedIgnacio AliagasTerry CrawfordJialin MaoSeth F HarrisMin XuShumei WangPing WuFang MaKevin ClarkJessica SimsYiming XuYutian PengElizabeth SkippingtonYing YangJanina ReederSavita UbhayakarMatt BaumgardnerZhengyin YanJacob ChenSummer ParkHua ZhangChun-Wan YenMaria LorenzoNicholas SkeltonXiaorong LiangLiuxi ChenBridget HoagChun Sing LiZhiguo LiuJohn WaiXingrong LiuJun LiangMan-Wah TanPublished in: mBio (2024)
infection. Structural analyses of novel inhibitors explain differences in biochemical and whole-cell activity across bacterial clades and underscore why this discovery may have broad translational impact on treatment of the most recalcitrant bacterial infections.