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Onygenaleosides A-F, 6/5 Bicyclic Ring Skeleton Triterpene Glycosides with Insecticidal Activity from Onygenales sp. YX1425.

Kang ChenJianshuang ZhouBaoqing DunWenfei ZhangChen WangLinan XieYuquan Xu
Published in: Journal of natural products (2023)
Six new squalene derived polyether glycosides, onygenaleosides A-F ( 1 - 6 ), that possess a 6/5 bicyclic fused ring skeleton were isolated from the cultures of Onygenales sp. YX1425, along with two known analogues ( 7 and 8 ). The planar structures of the new compounds were elucidated based on analysis of NMR and MS spectroscopy data, and the absolute configuration of 1 was determined by the advanced Mosher method and quantum chemical calculations. Compound 2 was active against Spodoptera frugiperda with an LC 50 value of 193.4 ± 1.1 μg/mL.
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