Inhibition of Ceramide Accumulation in Podocytes by Myriocin Prevents Diabetic Nephropathy.

Chang Yun WooJi Yeon BaekAh Ram KimChung Hwan HongJi Eun YoonHyoun Sik KimHyun Ju YooTae Sik ParkRanjan KcKi Up LeeEun Hee Koh

Published in: Diabetes & metabolism journal (2019)

We showed that mitochondrial ceramide accumulation may result in podocyte damage through ROS production. Therefore, this signaling pathway could become a pharmacological target to abate the development of diabetic kidney disease.

Keyphrases

diabetic nephropathy
signaling pathway
oxidative stress
type diabetes
dna damage
pi k akt
cell death
epithelial mesenchymal transition
reactive oxygen species
wound healing
cell proliferation
endothelial cells