Ultra-short cell-free DNA fragments enhance cancer early detection in a multi-analyte blood test combining mutation, protein and fragmentomics.

Fenfen WangXinxing LiMengxing LiWendi LiuLingjia LuYang LiXiaojing ChenSiqi YangTao LiuWen ChengLi WengHongyan WangDongsheng LuQianqian YaoYingyu WangJohnny WuTobias WittkopMalek FahamHuabang ZhouHeping HuHai JinZhiqian HuDing MaXiaodong Cheng

Published in: Clinical chemistry and laboratory medicine (2023)

These results suggest synergistic properties of protein, genetic and fragmentomics features in the identification of early-stage cancers.

Keyphrases

early stage
protein protein
amino acid
binding protein
high resolution
genome wide
squamous cell
squamous cell carcinoma
cancer therapy
gene expression
copy number
radiation therapy
mass spectrometry
neoadjuvant chemotherapy
young adults
rectal cancer
locally advanced
lymph node metastasis